The preimplantation period of development is crucial for reproductive success. The health of an embryo during the preimplantation period affects many parameters later in life including birth weight, cardiovascular health, and blood pressure. Therefore it is desirable to understand the genetic, molecular, and cellular parameters that are indicative of embryo health.

Research Experience:

In this project we will use state-of-the-art-imaging methods to evaluate the health of preimplantation embryos. Mouse embryos will be used as a model system. Subsurface imaging of mitochondrial distribution and protein expression will be evaluated using fluorescence microscopy, confocal microscopy, and a newly developed method, quadrature tomographic microscopy (QTM). Mitochondrial distribution patterns are believed to be an important indicator of preimplantation embryonic health.

The visiting secondary school teacher will be expected to spend 6 weeks in the laboratory, Monday through Thursday, approximately 8 am to 5 p.m. At the end of the training period the teacher will be able to bring knowledge of state-of-the-art microscopic imaging techniques back to his or her classroom.